The topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. Special focus is highlighted in the areas of Mechanisms of Photoreceptor Degeneration and Cell Death (extremely important because very little is known how or why photoreceptors die in these diseases, despite an abundance of genetic information), Age-Related Macular Degeneration (with several novel approaches to its analysis), Usher Syndrome (the most severe form of retinitis pigmentosa, which includes an early or congenital loss of hearing along with blindness), and Gene Therapy. In addition, the section on Basic Science Related to Retinal Degeneration is particularly strong with several laboratories reporting on new discoveries in the area of outer segment phagocytosis, a key component of photoreceptor-retinal pigment epithelial cell interactions in normal and degenerating retinas.1. IDENTIFICATION OF THE RP1 AND RP10 (IMPDH1) GENES CAUSING AUTOSOMAL DOMINANT RP.- 2. ON THE ROLE OF IMPDH1 IN RETINAL DEGENERATION.- 3. AN INTEGRATED GENETIC APPROACH TO IDENTIFY CANDIDATE GENES FOR HUMAN CHROMOSOME 6q-LINKED RETINAL DISORDERS.- 4. MOUSE GENETIC APPROACHES TO ACCESS PATHWAYS IMPORTANT IN RETINAL FUNCTION: A VALUABLE TOOL FOR THE ASSESSMENT OF NOVEL GENE THERAPIES.- 5. RETINAL DEGENERATIVE DISORDERS IN SOUTHERN AFRICA:A MOLECULAR GENETIC APPROACH.- 6. COMPARING ROD AND CONE FUNCTION WITH FUNDUS AUTOFLUORESCENCE IMAGES IN RETINITIS PIGMENTOSA.- 7. A MODIFIED PROTOCOL FOR THE ASSESSMENT OF VISUAL FUNCTION IN PATIENTS WITH RETINITIS PIGMENTOSA.- 8. PRENATAL HUMAN OCULAR DEGENERATION OCCURS IN LEBERS CONGENITAL AMAUROSIS: (LCA 1 and 2).- 9. LEBER CONGENITAL AMAUROSIS GENOTYPING REQUIRED FOR POSSIBLE INCLUSION IN A CLINICAL TRIAL.- 10. TREATMENT OF CYSTOID MACULAR EDEMA RELATED TO RETINITIS PIGMENTOSA WITH INTRAVITREAL TRIAMCINOLONE ACETONIDE: lC1
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