The Role of Brain Dopamine [Paperback]

As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.The Role of Dopamine in the Control of Neurobiological Functions.- Parkinsons Disease.- Morphological Basis for the Pathobiochemistry of the Nigrostriatal Dopamine Systems.- Pathobiochemistry of Parkinsons Disease.- Protein Phosphorylation and Synthesis.- Molecular Plasticity of the Nigrostriatal DA System in Man.- Presynaptic Feedback Regulation.- Therapeutic Consequences of Autoreceptor Stimulation.- Basic Principles of Receptor Regulation.- Transneuronal Feedback Regulation.- Denervation Supersensitivity.- Neuronal Sprouting and Re-innervation by Grafts.- Neuronal Reserve Capacity.- DA as a Hormone.- EvilsY