Sepsis represents a life threatening condition to ICU patients. The evolution of sepsis to severe sepsis or septic shock may occur in an unpredictable way. In the coming millennium the prevention and management of sepsis and organ dysfunction will present a real challenge for researchers and clinicians.A Tribute to Roger BoneSepsis represents a life threatening condition to ICU patients. The evolution of sepsis to severe sepsis or septic shock may occur in an unpredictable way. In the coming millennium the prevention and management of sepsis and organ dysfunction will present a real challenge for researchers and clinicians.Inflammation Injury, inflammation, sepsis Genetic predisposition to sepsis and organ failure SIRS in the 21th century Prevention and treatment of sepsis Sepsis and MODS What is clinical relevance? Regulation of the lung inflammatory response Endotoxemia in critical illness New and old markers in sepsis From cytokines through immune effector cells to the body Intravenous ummunoglubulins Splacninc perfusion: a critical problem in sepsis? Metabolism and CO2 consumption in trauma and sepsis.Springer Book Archives