Skin Permeability [Paperback]

Skin Permeability. By Prof. Dr. H. Schaefer, Valbonne/France, Prof. Dr. A Zesch, Berlin, and Prof. Dr. G. Stüttgen, Berlin (With 139 Figures).- I. Introduction.- 1. To the Reader.- 2. Definitions.- II Morphologic Basis of Absorption by Human Skin.- 1. Skin Surface.- 2. Horny Layer.- 3. Epidermis.- 4. Dermis (Corium).- 5. Subcutis.- III. Methods for Measurement of Absorption.- 1. Animal Experiments.- 2. In Vitro Methods.- a) Disappearance Measurements.- b) Penetration Into the Isolated Horny Layer.- c) Diffusion Through Horny Layer and Epidermis Into Dermis.- d) Diffusion Through Horny Layer and Epidermis.- e) Diffusion Through the Total Skin Specimen.- f) Penetration Into Single Layers of the Skin.- g) Inverse Penetration.- 3. In Vivo Methods.- a) Disappearance Measurements.- b) Measurement in the Horny Layer.- c) Appearance in the Skin and Inner Organs (Autoradiography).- d) Measurement of Total Body Content.- e) Measurement of Skin Clearance.- f) Measurement in Exudates.- g) Measurement of Appearance in the Serum.- h) Radioimmunoassay.- i) Determination in the Urine.- j) Determination of Concentration in the Horny Layer, Epidermis and Dermis.- k) Determination of Appearance in the Epidermis and Dermis by Secondary Parameters.- l) Determination of Skin Reactivity.- m) Determination of Allergenic Potency.- n) Determination and Estimation of Therapeutic Efficiency.- o) Determination of Migration From the Vessels of the Underlying Tissue Into the Skin and to the Skin Surface.- 4. Prerequisites for the Measurement of Permeation Parameters With Radioactively Labelled Substances.- 5. Comparison of in Vivo and in Vitro Permeability.- 6. Compartments of Skin Permeation.- a) Skin Surface.- b) Horny Layer.- c) Percutaneous Resorption and Systemic Treatment.- d) Binding to the Skin.- e) Transfollicular Absorption.- 7. Transformation and Metabolism of Drugs in the Skin.- a) Autodisintegration by Radiolysis.- b) Chemical Decomposition.- c) Passive Metabolism.- d) Micl“=