Small Stress Proteins [Paperback]

Evolution and Diversity of Prokaryotic Small Heat Shock Proteins.- 1 Introduction.- 2 sHsps in Prokaryotes.- 3 Are sHsps Dispensable in Some Pathogenic Bacteria?.- 4 Phylogenetic Analysis of Prokaryotic sHsps.- 5 Lateral Transfer or Convergent Evolution of Prokaryotic sHsp Genes.- 6 Secondary Structure Prediction of the a-Crystallin Domain.- 7 Alignment and Secondary Structure Prediction of the N-Terminal Domain.- 8 Summary and Concluding Remarks.- References.- Discovery of Two Distinct Small Heat Shock Protein (HSP) Families in the Desert Fish Poeciliopsis.- 1 Introduction.- 2 Variation in Small HSPs Among Desert Species of Poeciliopsis.- 2.1 Results of Survey Among Species.- 2.2 HSP Isoforms as Primary Gene Products.- 2.3 Conclusions.- 3 Variation in Small HSPs Within Poeciliopsis Species.- 3.1 Results of Within-Species Survey.- 3.2 Conclusions.- 4 Discovery of Two Classes of Small HSPs in a Single Taxon.- 4.1 Differential Synthesis.- 4.2 Phosphorylation State of the Small HSPs.- 4.3 Sequence Analysis.- 4.4 Evolutionary Analysis.- 4.5 Conclusions.- References.- Chaperone Function of sHsps.- 1 Introduction.- 2 General Aspect of Chaperone function.- 2.1 Chaperones.- 2.2 Analysis of Chaperone function.- 3 The Chaperone Properties of sHsps.- 3.1 In Vivo Functions of sHsps.- 3.2 sHsps Bind Non-Native Protein.- 3.3 Complex Formation and Substrate Range.- 3.4 The Substrate Binding Site.- 3.5 Mechanism of Substrate Binding.- 3.6 Regulation of Functional Properties.- 3.7 sHsps in the Context of the Cellular Chaperone Machinery.- 4 Conclusions.- References.- The Small Heat Shock Proteins of the Nematode Caenorhabditis elegans: Structure, Regulation and Biology.- 1 Introduction.- 2 The Small Heat Shock Protein Family of C. elegans.- 3 The 16-kDa Stress Proteins (Hspl6s).- 3.1 Hspl6 Gene Organization.- 3.2 Hspl6 Regulation.- 3.3 Biochemical Properties of Hspl6s.- 3.4 Uses of Hspl6 Promoters in C. elegans Research.- 4 The 12-kDa Small Heat Shock Proteins (Hspl2s).- 5 SIP-1.- 6lS.