Somitogenesis [Hardcover]

This book will be of interest to scientists working in the fields of cell and developmental biology. The chapters cover topics that capture the spirit of this dynamic discipline by integrating contemporary research with the classical embryological literature.

1. Formation and Differentiation of Avian Somite Derivatives........ 1 Bodo Christ and Martin Scaal Abstract................ 1 Introduction ................. 1 Dermomyotome................ 2 Sclerotome................. 14 Outlook............. 29 2. Avian Somitogenesis: Translating Time and Space into Pa ttern.......... 42 Beate Brand-Saberi, Stefan Rudloff and Anton J. Gamel Abstract............. 42 Introduction.............. 42 Epithelialization of the segmental plate............. 43 The anterior posterior polarization of the paraxial mesoderm.............. 46 Resegmentation of the somitic derivatives.............. 49 Regionalization of somites and segmental plate............... 49 Oscillations in gene expression underlying somitogenesis........... 50 Conclusion and future considerations.............. 52 3. Genetic analysis of somite formation in laboratory fish models........... 58 Christoph Winkler and Harun Elmasri Abstract............. 58 Introduction........... 58 Genetically dissecting the clock in zebrafish: The Delta/Notch somitogenesis mutants.............. 60 Dissecting the wave front in zebrafish: FGF signalling and Tbx24............ 62 Other pathways implicated in somitogenesis............ 64 Medaka: a model complementary to zebrafish............ 64 Somite formation in the teleost medaka............. 65 Medaka somitogenesis mutants............. 66 Medaka somite mutants with PSM prepatterning defects............ 67 Medaka mutants with defective somite polarity............. 67 Conclusions and outlook............. 69 4. Old wa res and new: five decades of investigation of somitogenesis in Xenopus laevis......... 73 Duncan B. Sparrow Abstract............. 73 Introduction............ 7l|