Specificity of Proteolysis [Paperback]

Specificity of Proteolysis presents a survey and conclusionson the action or proteinases - enzymes which are cleavingproteins or peptides. The specificity of proteinases whichis determined as the sequence of amino acids at the cleavagesite of a substrate, is an important criteria to choose anenzyme as tool in protein research. Whenever one is lookingfor an enzyme to act at a defined site or to give definedcleavage products one will find comprehensive information inthis work.Comprehensive information about more than 280 endopeptidaseswhich are based on the database LYSIS including acalculation program to determine cleavage sites, is given inthe book.Specificity of Proteolysis presents a survey and conclusionson the action or proteinases - enzymes which are cleavingproteins or peptides. The specificity of proteinases whichis determined as the sequence of amino acids at the cleavagesite of a substrate, is an important criteria to choose anenzyme as tool in protein research. Whenever one is lookingfor an enzyme to act at a defined site or to give definedcleavage products one will find comprehensive information inthis work.Comprehensive information about more than 280 endopeptidaseswhich are based on the database LYSIS including acalculation program to determine cleavage sites, is given inthe book.1 Introduction.- 2 Nomenclature and Conventions.- 2.1 EC Numbers.- 2.2 Enzyme Names.- 2.3 Enzyme and Substrate Codes.- 2.4 Subsite Nomenclature.- 2.5 Bibliography.- 3 Data Treatment.- 3.1 Data Bank LYSIS.- 3.2 Statistical Approach to Specificity.- 3.2.1 Calculations.- 3.2.2 Sources of Errors and Limits.- 3.2.3 Influence of Subsites on Chymotryptic Cleavages.- 3.2.4 Roles of Subsites P4-P3 in Cleavages by Pepsin.- 3.2.5 Fixation Preference of Chymotrypsin and Pepsin.- 3.2.6 Predictions of Cleavage Probability.- 3.2l³V