Sphingolipids and Metabolic Disease [Hardcover]

Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms, like endocrine disruption by environmental pollutants, also gain support from the literature). In animals, overnutrition is initially handled by adipose tissue expansion; however, exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle, heart, liver, and others. Failure of these tissues to clear excess lipids through either metabolism or sequestration into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells. In particular, aberrant generation of bioactive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance, inflammation, cardiomyopathy, and others. This volume addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes.

This book addresses not only the fundamentals of sphingolipid metabolism and analysis, but also the roles of sphingolipids in these disease processes. It features findings that sphingolipids may regulate cholesterol homeostasis through SREBP and lipid efflux.

Sphingolipid Metabolism and Analysis in Metabolic Disease.- Sphingolipids and Cardiovascular Diseases: Lipoprotein Metabolism, Atherosclerosis and Cardiomyopathy.- Heart Sphingolipids in Health and Disease.- Blood Sphingolipids in Homeostasis and Pathobiology.- Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity.- Sphingolipids and Hepatic Steatosis.- Glycosphingolipids and Insulin Resistance.- Glyco Sphingolipids and Kidney Disease.- Sphingolipid Synthetic Pathways are Major Regulators of Lipid Homeostasis.

L. Ashley Cowart obtained her BS in Biology in 1995 from Furman University in Greenville, South Carolina, and her PhD in Biochemistry il³