The aim of this volume is to make computer programs for analyzing human genetic data more easily accessible to the beginner.Statistical Human Genetics: Methods and Protocols, Second Edition?provides updated and new chapters detailing genetic terms, analysis software, and how to interpret the program outputs. Written in the highly successful?Methods in Molecular Biology?series format, the chapters?include introductions to their respective topics, step-by-step?instructions,?and tips on troubleshooting and avoiding known pitfalls.?
The purpose of?Statistical Human Genetics: Methods and Protocols, Second Edition?is to ensure successful and meaningful results in the fast-growing field of genetic epidemiology.
1. Statistical Genetic Terminology
Robert Elston, Jaya Satagopan, and Shuying Sun
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2. Identification of Genotype Errors
Jeffery OConnell and Yin Yao
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3. Detecting Pedigree Relationship Errors
Lei Sun
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4. Identifying Cryptic Relationships
Lei Sun, Apostolos Dimitromanolakis, and Wei-Min Chen
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5. Estimating Allele Frequencies
Indra Adrianto and Courtney Montgomery
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6. Testing Departure from Hardy-Weinberg Proportions
Jian Wang and Sanjay Shete
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7. Estimating Disequilibrium Coefficients
Maren Vens and Andreas Ziegler
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8. Detecting Familial Aggregation
Adam C. Naj and Terri H. Beaty
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9. Estimating Heritability from Twin Studies
Katrina Grasby, Karin J.H. Verweij, Miriam A. Mosing,lÅ
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