Stem Cell Therapeutics for Cancer [Hardcover]

Stem Cell Therapeutics for Cancer covers the application of stem cells in various cancers, with an emphasis on the aspects of these strategies that are critical to the success of future stem cell-based therapies for cancer. Topics covered in the book include stem cell sources, tumor specificity, targeted therapeutics, visualizing the stem cell, and therapeutic agent pharmacokinetics. Each chapter contains a brief introduction to the cancer, followed by an exploration of how engineered stem cells have been utilized to cure the disease in mouse models and in early phase clinical trials.

• Comprises of sections on stem cell therapy in brain cancers, lung cancers, breast cancers, as well as stem cells in combination with other therapies
• Focuses on the practical applications of using stem cells as gene delivery agents to treat cancer
• Includes coverage of cutting-edge molecular imaging techniques in stem cell therapeutics for a variety of tumour types

 

Contributors vii

Preface xi

Section 1 Introduction 1

1 Stem Cell Sources and Their Potential for Cancer Therapeutics 3
Khalid Shah

Section 2 Migration and Fate of Stem Cells 11

2 The Role of CXCR4 as a Mediator of Glioma-Tropic Neural Precursor Cell Migration 13
Moneeb Ehtesham, Elliot Min, and Rebecca Kasl

3 Tumor Tropism of Mesenchymal Stem Cells 21
Paula Y. P. Lam and Ivy A.W. Ho

Section 3 Stem Cell Therapy in Brain Cancer 39

4 Stem Cell-Mediated Trail Therapy for Highly Aggressive Brain Tumors 41
Khalid ls´