This detailed volume brings together a diverse collection of stem cell-derived model-based toxicity assays, from those routinely used to those deemed to have considerable potential. With a focus on differentiated tissues, the chapters explore numerous cardiotoxicity applications as well as coverage of neurotoxicity, hepatotoxicity, and more. Written for the Methods in Pharmacology and Toxicology series, the contents of this book aim to enable adoption of these protocols in laboratories that are interested in entering the field as well as to facilitate the transfer of best practices between laboratories that are already actively pursuing these technologies.
Authoritative and cutting-edge, Stem Cell-Derived Models in Toxicology serves as a vital resource for researchers aiming to improve risk assessment in drug discovery and design.
1. Stem CellDerived Models for Safety and Toxicity Assessments: Present and Future Studies in the Proclinical Space
Gary Gintant and Stefan Braam
2. Human Pluripotent Stem Cell Test for Assessing the Potential Teratogen Risk
Sei Kameoka and Eric Chiao
3. Cardiac Action Potential Measurement in Human Embryonic Stem Cell Cardiomyocytes for Cardiac Safety Studies Using Manual Patch-Clamp Electrophysiology
Muthukrishnan Renganathan, Haiyang Wei, and Yong Zhao
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