Structural Genomics and Drug Discovery Methods and Protocols [Hardcover]

Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug discovery. The methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Structural Genomics and Drug Discovery: Methods and Protocols seeks to aid scientists in the further study into structural genomics approach as an efficient initial step toward drug discovery and the methods described will be useful to anyone interested in moving in this direction.

1. Data Management in the Modern Structural Biology and Biomedical Research Environment

Matthew D. Zimmerman, Marek Grabowski, Marcin J. Domagalski, Elizabeth M. MacLean, Maksymilian Chruszcz, and Wladek Minor

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2. Structural Genomics of Human Proteins

Khan Tanjid Osman and Aled Edwards

Corin Yeats, Benoit H. Dessailly, Elizabeth M. Glass, Daved H. Fremont, Christine A. Orengo

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4. Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery

Isabelle Q.H. Phan, Robin Stacy, ?and Peter J. Myler

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5. High Throughput Cloning for Biophysical Applications

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