This book describes recent developments concerning structural, functional and possible therapeutic aspects of one particular CAM, the neural cell adhesion molecule (NCAM).
Preface Structural Biology of NCAMVladislav Soroka, Christina Kasper and Flemming M. PoulsenExtracellular Protein Interactions Mediated by NCAM: Heterophilic Interactions between NCAM and Cell Adhesion Molecules, Extracellular Matrix Proteins, and VirusesJanne Nielsen, Nikolaj Kulahin and Peter S. WalmodIntracellular Ligands of NCAMBettina B?ttner and R?diger HorstkorteNCAM and the FGF receptorVladislav V. KiselyovThe Role of ATP in the Regulation of NCAM FunctionMartin V. H?bschmann and Galina SkladchikovaPolysialylation of NCAMHerbert Hildebrandt, Martina M?hlenhoff and Rita Gerardy-SchahnStructural Basis for the Polysialylation of NCAMKaren J. ColleyThe Role of PSA-NCAM in Adult NeurogenesisEduardo Gascon, Laszlo Vutskits and Jozsef Zoltan KissUse of PSA-NCAM in Repair of the Central Nervous SystemAbderrahman El Maarouf and Urs RutishauserSignaling Pathways Involved in NCAM-induced Neurite OutgrowthDorte Kornerup Ditlevsen and Kateryna KolkovaRole of Growth-Associated Protein GAP-43 in NCAM-mediated Neurite OutgrowthIrina Korshunova, Mark MosevitskyNCAM and Lipid RaftsGro Klitgaard Povlsen and Dorte Kornerup DitlevsenNCAM and Epidermal Growth Factor Receptor: Signaling CrosstalkGro Klitgaard PovlsenBiosynthesis of NCAMKateryna KolkovaSoluble NCAMThomas SecherRole of NCAM in Spine Dynamics and SynaptogenesisDominique Muller, Pablo Mendez, Mathias De Roo, Paul Klauser, S. Steen and Lorenzo PogliaNCAM in Long-termPotentiation and LearningBarbara P. Hartz and Lars Christian B. R?nnRole of NCAM in Emotion and LearningLisa Conboy, Reto Bisaz, Kamila Markram and Carmen SandiNCAM in Neuropsychiatric and Neurodegenerative DisordersLeann H. Brennaman and Patricia F. ManessNCAM in Cancer: Expression and MechanismsSilvia Zecchini and Ugo CavallaroNCAM Mimetic Peptides: An UpdateVladimir l³n