Studies on Alzheimer's Disease [Paperback]

This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as oxidative stress, in the pathology of Alzheimers disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimers Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damageand describes the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers and clinicians studying the development of and treating patients with Alzheimers Disease.This volume reviews basic science and clinical knowledge of the role of oxidative stress in the pathology of Alzheimers disease. Describes current diagnostic tools and laboratory methods and technology, suggests prevention and treatment options and more.

Section 1: Hypotheses.- Oxidative stress: impact in neuroscience research.- Oxidative stress and Alzheimers disease.- Inflammation and Oxidation: a link in Alzheimer disease pathogenesis.- GAPDH:?-amyloid mediated iron accumulation in Alzheimers disease.- A? in mitochondria: one piece in the Alzheimers disease puzzle.- The role of the plasma membrane redox system in the pathognesis of Alzheimers disease.- Section 2: Mechanisms.- Metal dysfunction in Alzheimers disease.- Brain Oxidative Stress in the Pathogenesis and Progression of Alzheimers Disease.- Cholesterol metabolism and oxidative stress in Alzheimers disease.- Brain hypometabolism, oxidative stress, maternal transmission and risk of late-onset Alzheimers disease.- Stress and HPA axis dysfunctionlsI