Many breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.
Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described.
The chapter Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses is available open access under a CC BY 4.0 license via link.springer.com.
Chapter 1: Systems Biology of Genome Structure and Dynamics.- Chapter 2: A Systems Perspective of Complex Diseases: from Reductionism to Integration.- Chapter 3: Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems.- Chapter 4: Systems Biology of RNA Binding Proteins in Amyotrophic Lateral Sclerosis.- Chapter 5: Systems Approaches to Map in vivo RNA-Protein Interactions in Arabidopsis thaliana.- Chapter 6: Systems-Level Analysis of Bacterial Regulatory Small RNA Networks.- Chapter 7: Epioncogenes in CancerIdentification of Transcriptomic and Epigenomlý
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