Systems Biology of Parkinson's Disease [Paperback]

The Systems Biology of Parkinsons Disease will be underpinned by new measurement techniques. This is particularly true of the pathology of Parkinson's Disease, where recent developments in brain imaging have offered new insights into the morphology of dopaminergic neurons that have profound implications for the special vulnerability and role of this class of neurons.This book shows how methods of systems biology have the potential to accelerate research into diseases like Parkinson's disease (PD). It comprises a set of eight studies of important aspects of PD, covering all relevant scales of space and time.Imaging of dopaminergic neurons and the implications for Parkinsons disease.- Modelling and simulation of brain energy metabolism: energy and Parkinson's disease.- Systems Biology of Aging: Opportunities for Parkinsons Disease.- Mitochondrion- and Endoplasmic Reticulum-Induced SK Channel Dysregulation as a Potential Origin of the Selective Neurodegeneration in Parkinsons Disease.- Energetics of Ion Transport in Dopaminergic Substantia nigra Neurons: ion exchange dynamics at the pacemaking membrane.- Real-time In Vivo Sensing of Neurochemicals.- Modeling protein and oxidative metabolism in Parkinson's disease.- Mathematical Models of Dopamine Metabolism in Parkinsons Disease.- Index.

From the reviews:

This book is based on the fascinating concept of applying systems biology & to understand how things work and apply this approach to the study of Parkinsons disease. & The book is intended for Parkinsons disease specialists and researchers, and it is best suited for researchers. It is well written by credible authorities in the field. & The book accomplishes its main goals without question. This is a novel approach to an important clinical condition. (Joseph I. Sirven, Doodys Review Service, September, 2012)

This text is the first to present a study of Parkinsons disease from a Systems Biology pls%