Tissue Oxygenation in Acute Medicine [Paperback]

Researchers from many disciplines, with both basic and clinical perspectives, came together in this volume to review and debate issues pertaining to the investigation and control of tissue oxygenation in acute medicine, as well as treatments to improve tissue oxygenation when abnormal. In this latter context, special emphasis is placed on understanding the effect of blood substitutes on the circulation and on the potential roles of this family of compounds in clinical medicine.Researchers from many disciplines, with both basic and clinical perspectives, came together in this volume to review and debate issues pertaining to the investigation and control of tissue oxygenation in acute medicine, as well as treatments to improve tissue oxygenation when abnormal. In this latter context, special emphasis is placed on understanding the effect of blood substitutes on the circulation and on the potential roles of this family of compounds in clinical medicine.Physiology of Oxygen Delivery.- Role of the Cardiorespiratory System in Delivering Oxygen.- Intraorgan Heterogeneity of Blood Flow, Oxygen Consumption and Tissue Oxygenation.- The Microcirculation and Tissue Oxygenation.- Oxygen Distribution and Consumption by the Microcirculation and the Determinants of Tissue Survival.- Oxygen Signaling Cascades in Mammalian Cells.- Hypoxia and Its Consequences.- Hypoxic Hypoxia.- Circulatory Hypoxia.- Anemic Hypoxia.- Cytopathic Hypoxia: Mitochondrial Dysfunction as a Potential Mechanism Contributing to Organ Failure in Sepsis.- Poly (ADP-ribose) Synthetase Activation in Circulatory Shock.- Cellular Responses to Hypoxia: Possible Relevance to Multiple Organ Failure in Critical Illness?.- The Mitochondrial Permeability Transition.- Measuring Tissue Oxygenation.- The Available Clinical Tools  Oxygen-Derived Variables, Lactate, and pHi.- Microcirculatory Flows, Microcirculatory Responsiveness, Microcirculatory and Regional (Arteriolar/Venular) O2 Saturations.- Monitoring the Systemic Cil“Õ