Trafficking of GPCRs [Hardcover]

G protein-coupled receptors (GPCRs) constitute?the?largest superfamily of cell surface receptors that regulate a variety of cell functions. Over the past few decades great progress has been made in defining the roles of intracellular trafficking in controlling the functionality of the receptors as well as in the development of various human diseases. This volume of Progress in Molecular Biology and Translational Science?reviews the recent understanding of GPCR trafficking regulators and molecular mechanisms.

• Written by future leaders in the pain field
• Covers a wide range of targets
• Contains provocative ideas about GPCR trafficking

1. Arrestins: Critical Players in Trafficking of Many GPCRs
   Vsevolod V. Gurevich and Eugenia V. Gurevich
2. Regulation of GPCR Trafficking by Ubiquitin
   Justine E. Kennedy and Adriano Marchese
3. Rhodopsin Trafficking and Mistrafficking: Signals, Molecular Components and Mechanisms
   Ina Nemet, Philip Ropelewski and Yoshikazu Imanishi
4. Intracellular Trafficking of Neuropeptide Y Receptors
   Karin M?rl and Annette G. Beck-Sickinger
5. Insights into Serotonin Receptor Trafficking: Cell Membrane Targeting and Internalization
   Mich?le Darmon, Sana Al Awabdh , Michel-Boris Emerit? and Justine Masson?
6. Calcium-Sensing Receptor: Trafficking, Endocytosis, Recycling and Importance of??? Interacting Proteins
   Kausik Ray
7. Trafficking of ? Adrenergic Receptors: Implications in Intracellular Receptor Signaling