Transcriptional and Translational Regulation of Stem Cells [Hardcover]

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes  achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic  (1) illustrating the general principles outlined above through a series of different stem cell examples  embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

1. The stem cell state; Gary R. Hime and Helen E. Abud

2. Induction of pluripotency; Corey Heffernan, Jun Liu, Huseyin Sumer, Luis F. Malaver-Ortega, Rajneesh Verma, Edmund Carvalho and Paul J. Verma

Model stem cell systems

(A) Invertebrate

3. Germline stem cells and their regulation in the nematode Caenorhabditis elegans; Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter and Judith Kimble

4. Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny; Helen White-Cooper and Simona Caporilli

5. Stem cells in the Drosophila digestive system; Xiankun Zeng, Chhavi Chauhan, and Steven X. Hou