Transient Receptor Potential Channels [Hardcover]

Transient Receptor Potential Channels offers a unique blend of thoughtfully selected topics ranging from the structural biology of this fascinating group of ion channels to their emerging roles in human diseases. This single book covers TRP channels of yeasts, flies, fishes frogs and humans. And from the biophysics of primary thermo-sensory events in cells to the thermosensation at whole organism level, from physiology of pain to the development of pain-killers, from psychiatric illnesses to cancers, from skin cells to sperms, from taste buds to testes, from established facts to heated debates, this book contains something for every TRP enthusiasts, beginner and expert alike. It includes crucial background information, critical analysis of cutting edge research, and ideas and thoughts for numerous testable hypotheses. It also shows directions for future research in this highly dynamic field. It is a book readers will be just as eager to give to others as keep for themselves.Transient Receptor Potential Channels presents a synthesis of selected topics ranging from the structural biology of this fascinating group of ion channels. TRP channels of yeasts, flies, parasites, fishes, frogs and human are all included in one comprehensive text.Contents. Preface. 1. Structural biology of TRP channels. 2. Functional and structural studies of TRP channels heterologously expressed in budding yeast. 3. Natural product ligands of TRP channels. 4. Synthetic modulators of TRP channel activity. 5. Study of TRP channels by automated patch clamp systems. 6. TRPC2: of mice but not men. 7. TRPM1: New trends for an old TRP. 8. The non-selective monovalent cationic channels TRPM4 and TRPM5. 9. TRPM7, the Mg2+ inhibited channel and kinase. 10. TRPM8 in health and disease: cold sensing and beyond. 11. TRPML1. 12. TRPML2 and the evolution of mucolipins. 13. The TRPML3 channel: from gene to function. 14. TRPV5 and TRPV6 in transcellular Ca2+ transport: regl#0