Tumor Models in Cancer Research [Paperback]

The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the routine conduct of screening for potential new therapeutics is coming more slowly but is coming. Increasing numbers of genetically engineered mice are available, some with conditional activation of oncogenes, some with multiple genetic changes providing mouse models that are moving closer to the human disease.

Since the first edition of this book there has been great progress in the development of genetically engineered mouse (GEM) models of cancer. This revised and updated edition comprehensively describes the state-of-the-art in animal tumor model research.

TUMOR MODELS IN CANCER RESEARCH2nd editionBeverly A TeicherTable of ContentsINTRODUCTION1. Perspectives on the History and Evolution of Tumor ModelsShannon Decker and Edward SausvilleTRANSPLANTABLE SYNGENEIC RODENT TUMORS2. Murine L1210 and P388 LeukemiasWilliam R Waud3. Transplantable Syngeneic Rodent TumorsLisa Polin, Thomas H. Corbett, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White, Juiwanna Kushner, Stuart Hazeldine, Richard Moore, James Rake, and Jerome P. Horwitz4. B16 Murine Melanomas : Historical Perspective on the Development of a Solid Tumor ModelEnrique AlvarezHUMAN TUMOR XENOGRAFTS5. Human Tumor Xenograft Efficacy ModelsMing Liu and Daniel Hicklin6. Imaging the Steps of Metastasis at the Macro and Cellular Level with Fluorescent Proteins in Real TimeRobert M. Hoffman7. Patient-derived Tumor Models and ExplantsHeinz-Herbert Fiebig and Angelika M. Burger8. The Pediatric Preclinical Testing ProgramChristopher L. Morton and Peter J. Houghton9. Imaging Efficacy in Tumor ModelsVinod Kaimal, Wilbur R. Leopold, and Patrick McConvilleCARCINOGEN-INDUCED TUMORS10.lcO