Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs.
The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy?to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance,?but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune?suppression to make any progress in the field and this monograph provides these important insights.
Chapter 1 ?Regulatory T Cells and Cancer&..Mary Jo Turk
Chapter 2 Th17 cells in cancer&..Chrystal M. Paulos, Michelle H. Nelson and Xue-Zhong Yu
Chapter 3? Mast cells and immune response in cancer&.. Paola Pittoni and Mario P. Colombo
Chapter 4? Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance&..
Paolo Serafini and Vincenzo Bronte
Chapter 5 Immunobiology of Dendritic Cells in Cancer&..Michael R. Shurin, Anton Keskinov and Gurkamal S. Chatta
Chapter 6 Macrophages and Tumor Development&..Suzanne Ostrand-Rosenberg
Chapter 7 Angiogenesis and Immune SuppressiolC(
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