Vaccine Adjuvants [Paperback]

A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.A cutting-edge review of the major research areas of adjuvant discovery, design, development, and use. The authors lay down a rational basis for vaccine adjuvant function and analyze a number of significantly distinct adjuvant-active molecules to illuminate the principles of their function and use. The focus is on specific receptor-ligand interactions, including the molecular features needed for a compound to possess adjuvant activity. The critical interface zone between the innate and adaptive immune systems is also analyzed to show how adjuvants exert their effects on T- and B-cell activation. Additional chapters address the possibility of tailoring adjuvants to yield optimally safe and effective responses.Microbial Pathogenesis and the Discovery of Toll-Like Receptor FunctionBruce BeutlerDendritic Cells: Targets for Immune Modulation by Microbes and ImmunologistsBali Pulendran, Anshu Agrawal, Stephanie Dillon, and Sudhanshu AgrawalAchieving Transcriptional Specificity in NF-kB-Dependent Inflammatory Gene ExpressionGioacchino NatoliAdjuvants and the Initiation of T-Cell ResponsesMatthew F. Mescher, Julie M. Curtsinger, and Marc JenkinsMechanism for Recognition of CpG DNAKiyoshi Takeda, Hiroaki Hemmi, and Shizuo AkiraCpG ODN As a Th1 Immune Enhancer for ProphyllÓh