1 Introduction.- 1.1 The Search for Principles of Physiological Organization in Vertebrate Circadian Systems.- 1.2 Zeitgebers, Entrainment, and Masking: Some Unsettled Questions.- 2 Pathways of Zeitgeber Signals.- 2.1 Comparative Aspects of Retinal and Extraretinal Photosensory Input Channels Entraining Endogenous Rhythms.- 2.2 Neuroanatomical Pattern of Endocrine and Oscillatory Systems of the Brain: Retrospect and Prospect.- 2.3 Unspecific Optic Fibres and Their Terminal Fields.- 2.4 Characteristics of the Interaction Between the Central Circadian Mechanism and the Retina in Rabbits.- 3 The Role of the Nucleus Suprachiasmaticus.- 3.1 Physiological Models of the Rodent Circadian System.- 3.2 Neuroanatomical Organization and Connections of the Suprachiasmatic Nucleus.- 3.3 CNS Structures Controlling Circadian Neuroendocrine and Activity Rhythms in Rats.- 3.4 The Neurophysiology of the Mammalian Suprachiasmatic Nucleus and Its Visual Afferents.- 3.5 Neurophysiological Studies of the SCN in the Rat and in the Java Sparrow.- 3.6 Neural Mechanisms in Avian Circadian Systems: Hypothalamic Pacemaking Systems.- 3.7 Limits of Entrainment to Periodic Feeding in Rats with Suprachiasmatic Lesions.- 4 The Role of the Pineal Organ.- 4.1 Phase Responses and Characteristics of Free-Running Activity Rhythms in the Golden Hamster: Independence of the Pineal Gland.- 4.2 Circadian and Infradian Activity Rhythms in the Mammalian Pineal Body.- 4.3 Electrophysiology of the Mammalian Pineal Gland: Evidence for Rhythmical and Non-Rhythmical Elements and for Magnetic Influence on Electrical Activity.- 4.4 Circadian Rhythms of the Isolated Chicken Pineal in Vitro.- 4.5 Endogenous Oscillator and Photoreceptor for Serotonin N-Acetyltransferase Rhythm in Chicken Pineal Gland.- 5 Systemic Aspects.- 5.1 Role of Hormones in the Circadian Organization of Vertebrates.- 5.2 The Neuropharmacology of Circadian Timekeeping in Mammals.- 5.3 Entraining Agents for the Circadian Adrenocortical Rhythm in thel๓3