Vesicle Trafficking in Cancer [Paperback]

Endocytosis and vesicular trafficking determine the landscape of the cells exterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer.This book reports on recent progress in understanding the role of vesicular transport in cancer, including recent studies which raise the intriguing possibility that drug-mediated normalization of vesicular transport may serve as a therapeutic goal in cancer.Preface.- Clathrin Mediated Endocytosis.- Intimate And Facultative? Regulation Of Clathrin-Mediated Endocytosis By The Actin Cytoskeleton.- Oncogenic Signaling From The Plasma Membrane.- Endocytosis In The Spatial Control Of Polarized Cell Functions.- Aberrant Vesicular Trafficking Contributes To Altered Polarity And Metabolism In Cancer.- Endocytosis And The Regulation Of Cell Signaling, Cell Adhesion, And Epithelial To Mesenchymal Transition In Cancer.- Efficient Enhancement Of Signaling Capacity: Signaling Endosomes.- Nuclear Functions And Trafficking Of Receptor Tyrosine Kinases.- Efficient Enhancement Of Signaling Capacity  The Ubiquitin System.-? Molecular Mechanism Of Ubiquitin-Dependent Traffic.- Cbl As A Master Regl#+