Viral Genome Replication [Paperback]

This book provides the first comprehensive review of viral genome replication strategies, emphasizing not only pathways and regulation but also the structure-function, mechanism, and inhibition of proteins and enzymes required for this process.

Genome replication strategies.- Model of Picornavirus RNA Replication.- Coronavirus Genome Replication.- Flaviviruses.- Hepatitis C Virus Genome Replication.- Brome Mosaic Virus RNA Replication and Transcription.- Retroviruses.- Hepadnaviral Genomic Replication.- Rhabdoviruses.- Orthomyxovirus Genome Transcription and Replication.- Arenaviruses: Genome Replication Strategies.- Core-Associated Genome Replication Mechanisms of dsRNA Viruses.- Poxviruses.- Herpesvirus Genome Replication.- Host Factors Promoting Viral RNA Replication.- Host Factors that Restrict Retrovirus Replication.- Elements, factors and enzymes: Structure-function and mechanism.- T4 Phage Replisome.- Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase.- RNA Virus Polymerases.- Human Immunodeficiency Virus Reverse Transcriptase.- Viral Helicases.- Integrase: Structure, Function, and Mechanism.- Antivirals: Targets, mechanisms and resistance.- Viral DNA Polymerase Inhibitors.- Viral RNA Polymerase Inhibitors.- HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance.- Lethal Mutagenesis.- Clinical Implications of Reverse Transcriptase Inhibitor Resistance.

From the reviews:

Viruses are primarily classified by the structure of their genomes. & they can be split into either DNA or RNA, single- or double-stranded, there is great diversity in the means by which their genomes are replicated. & the book describes the replication strategies of, with a couple of exceptions, each of the major viral groups. & I recommend this title to all those interested in viral replication. (Christopher Ring, Microbiology Today, November, 2009)

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