In Vitro Neurotoxicology Principles and Challenges [Paperback]

Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.Well-respected leaders in the field of in vitro neurotoxicology take a fresh look at their own and other's work, critically and comparatively analyzing it across experimental systems and toxicants, and synthesizing essential principles for in vitro neurotoxicity testing. Neurotoxicants of significance to human health are emphasized, especially those for which metabolism and dose-responses are well well studied both in vivo and in vitro: lead, mercury, organophosphorous insecticides, polychlorinated biphenyls and dioxin, ethanol, and endogenous proteins. The goal is to set out new concepts and research directions that will hasten significant improvement in the methods and systems for in vitro neurotoxicity testing.In Vitro Neurotoxicology: Introduction to ConceptsEvelyn Tiffany-CastiglioniPredictive Value of In Vitro Systems for Neurotoxicity Risk AssessmentMarion Ehrich and David C. DormanExposure-Dose-Response Paradigm as It Relates to ToxicogenomicsWilliam H. Hanneman, Melvin E. Andersen, Marie E. Legare, Christine T. French, Tami S. McMullin, Carolyn Broccardo, and Ruth E. BillingsIn Vitro Studies of Neurotoxicant Effects on Cellular HomeostasisGerald J. Audesirk and Ronald B. TjalkensRole of Apoptosis in NeurotoxicologyLori D. White, Sid Hunter, Michaell£*