The fourth edition of this classical reference book can once again be relied upon to present a cohesive and up-to-date exposition of all aspects of human and medical genetics. Human genetics has become one of the main basic sciences in medicine, and molecular genetics is increasingly becoming a major part of this field. This new edition integrates a wealth of new information - mainly describing the influence of the molecular revolution - including the principles of epigenetic processes which together create the phenotype of a human being. Other revisions are an improved layout, sub-division into a larger number of chapters, as well as two-colour print throughout for ease of reference, and many of the figures are now in full colour.
For graduates and those already working in medical genetics.
The fourth, completely revised edition of this classic reference work is a cohesive and up-to-date exposition of the concepts, results, and problems underlying theory and practice in human and medical genetics, and reflects the progress of the last ten years.
The ? rst edition of Human Genetics, Problems and Approaches , was published in 1970 by human geneticists Friedrich Vogel and Arno Motulsky as sole authors. The aim was broad coverage and in-depth analysis of both medical and human genetics with an emphasis on problems and approaches with occasional historical c- ments. This point of view was fully explained in an introductory chapter of the three previous editions (1970, 1976, 1997). The book acquired an excellent reputation as an advanced text of human genetics and has been translated into Italian, Japanese, Russian, Chinese, and Portuguese. Our general aims for the fourth edition remain similar and together with novel developments are now set out in the Introduction of this new fourth edition. Around 2004/2005, both Friedrich Vogel and Arno Motulsky, as well as the publishers, felt that the book should be continued with a new fourth el3-